Fatty deposits in the eye called Drusen are metabolic wastes that build up and can distort the vision, damage the macula, and lead to blindness… 

Each vegicap of Drusen Dissolve Between Meals supplies:

Coenzyme Factors:

Vitamin A (Retinyl Palmitate) 5000 IU 1.72 mg 100%

[I]ntake... associated significantly (P ≤ 0.0005) with decreased risk of late AMD: vitamin A, vitamin B6, vitamin C, folate, β-carotene, lutein and zeaxanthin, magnesium, copper, and alcohol. Source: Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2

Vitamin B13 (Centrophenoxine) 100 mg *

Centrophenoxine enhances uptake and then breaks down into DMAE providing lipofuscin scavenging. If Centrophenoxine is not available, substitute DMAE.

(Note: Magnesium is nature's Calcium Channel Blocker - see below) "Purpose: To investigate the role of Ca2+ in lipofuscin formation in human retinal pigment epithelial (RPE) cells that phagocytize bovine photoreceptor outer segments (POSs). Methods: Cultured human RPE cells fed with 2 × 107 per l bovine POS were treated with flunarizine, an antagonist of Ca2+ channel, or/and centrophenoxine, a lipofuscin scavenger.... Conclusions: The Ca2+ inflow initiated lipofuscin accumulation in RPE cells fed with POS. Flunarizine and centrophenoxine can decrease Ca2+ overload and lipofuscin formation in RPE cells, accompanied by maintaining cellular vitality." Source: Calcium overload is associated with lipofuscin formation in human retinal pigment epithelial cells fed with photoreceptor outer segments

The main results were better performance in psychometric tests (Pék et al., 1989) and a significant increase of the average intracellular water content (2.2-2.5% by weight) in the verum-treated group. The rehydration of the intracellular mass due to CPH treatment is consistent with the OH(*.) free radical scavenger properties of CPH and the predictions of the membrane hypothesis of aging. Source: Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial

Vitamin C (as Zinc Ascorbate) 30 mg 50%

[I]ntake... associated significantly (P ≤ 0.0005) with decreased risk of late AMD: vitamin A, vitamin B6, vitamin C, folate, β-carotene, lutein and zeaxanthin, magnesium, copper, and alcohol. Source: Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2

Vitamin E (as Mixed Tocopherols) 10 IU 33%

The eye is particularly susceptible to oxidative stress and disruption of the delicate balance between oxygen-derived free radicals and antioxidants leading to many degenerative diseases. Attention has been called to all isoforms of vitamin E, with α-tocopherol being the most common form. Though similar in structure, each is diverse in antioxidant activity. Preclinical reports highlight vitamin E's influence on cell physiology and survival through several signaling pathways by activating kinases and transcription factors relevant for uptake, transport, metabolism, and cellular action to promote neuroprotective effects. In the clinical setting, population-based studies on vitamin E supplementation have been inconsistent at times and follow-up studies are needed. Nonetheless, vitamin E's health benefits outweigh the controversies. The goal of this review is to recognize the importance of vitamin E's role in guarding against gradual central vision loss observed in age-related macular degeneration (AMD). Source: Molecular Mechanisms Underlying the Therapeutic Role of Vitamin E in Age-Related Macular Degeneration

Zinc (as Zinc Ascorbate) 5.3 mg 35%

Conclusions: Current evidence on zinc intake for the prevention of AMD is inconclusive. Based on the strength of AREDS, we can conclude that zinc treatment may be effective in preventing progression to advanced AMD. Source: A systematic review on zinc for the prevention and treatment of age-related macular degeneration

Chromium (GTF Chromium) 120 mcg 100%

Chromium is included to support sugar regulation and fat burning, as well as longevity. Chromium is the only essential mineral the kidneys do not retain. Repletion supports a 5-year increase in longevity potential.

Trivalent chromium is essential to normal carbohydrate, lipid and protein metabolism. Chromium is biologically active as part of an oligopeptide—chromodulin—potentiating the effect of insulin by facilitating insulin binding to receptors at the cell surface. With chromium acting as a cofactor of insulin, Cr activity in the organism is parallel to insulin functions. Cr(III) can help enhance the role of insulin, the critical hormone that controls blood sugar and helps bring glucose into cells where it’s used for bodily energy. Chromium deficiency has been suggested to lead to symptoms associated with adult-onset diabetes and cardiovascular disease, and these supplements have recently found potential as therapeutic agents in the treatment of adultonset diabetes. Cr(VI) is one of the few carcinogenic metals that directly reacts with DNA, forming adducts, and inducing mutations. The results of a wide range of studies indicate that the CpG1 methylation level of p16 could be used as a biomarker of epigenetic effect caused by Cr(VI) treatment, which can enhance cell damage by regulating its expression or affecting some transcription factors to combine with their DNA strand sites. In addition, it is difficult to distinguish between the effects caused by chromium(VI) and those caused by chromium(III ) since chromium(VI) is rapidly reduced to chromium(III ) after penetration of biological membranes and in the gastric environment. In addition to its role in glucose and lipid metabolism, chromium also functions as an antioxidant. Chromium (III) protects organism from oxidative stress associated with reactive oxygen species. These ROS extremely reactive chemical molecules, are considered toxic to produce oxidative damage to various cellular components which causes cellular dysfunction that accompanies aging process. The antiaging effect of chromium is undoubtedly related to the effect of chromium on insulin action. Chromium in a utilizable form, like dietary restriction, prevents hyperglycemia, hyperinsulinemia, protein glycation and extends life span. Because the body’s ability to control blood glucose is critical to many life functions, a consequence of Cr supplementation can be improved health and reproductive outcomes as well as improved survival rate or life span. Source: Chromium in Health and Longevity

Selenium (Methylselenocysteine) 70 mcg 100%

Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-inflammatory effects to the production of active thyroid hormone. In the past 10 years, the discovery of disease-associated polymorphisms in selenoprotein genes has drawn attention to the relevance of selenoproteins to health. Low selenium status has been associated with increased risk of mortality, poor immune function, and cognitive decline. Higher selenium status or selenium supplementation has antiviral effects, is essential for successful male and female reproduction, and reduces the risk of autoimmune thyroid disease. Prospective studies have generally shown some benefit of higher selenium status on the risk of prostate, lung, colorectal, and bladder cancers.... Source: Selenium and human health

Copper (as Glycinate) 0.7 mg 35%

[I]ntake... associated significantly (P ≤ 0.0005) with decreased risk of late AMD: vitamin A, vitamin B6, vitamin C, folate, β-carotene, lutein and zeaxanthin, magnesium, copper, and alcohol. Source: Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2

Magnesium (as Magnesium Taurate) 4 mg 1%

A high consumption of specific nutrients, i.e. β-carotene, lutein and zeaxanthin, copper, folate, magnesium, vitamin A, niacin, vitamin B6, vitamin C, docosahexaenoic acid, and eicosapentaenoic acid, was associated with a lower risk of progression of early to late AMD (high certainty of evidence). Source: What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review

Other Metabolic Factors:

Taurine (Magnesium Taurate) 46 mg *

The second-most depleted non-lipid compound in the macula was taurine, which is known to be highly enriched in the retina, more so than any other bodily tissue (Ripps & Shen, 2012). Photoreceptors accumulate taurine and critically depend on it for long-term survival (Rascher et al., 2004; Ripps & Shen, 2012; Schmidt et al., 1976).... The most enriched metabolite in the macula was NAAG, which is the third-most-prevalent neurotransmitter in the mammalian nervous system (Neale et al., 2000) after glutamate and taurine. Source: Spatial distribution of metabolites in the retina and its relevance to studies of metabolic retinal disorders

MSM (Methylsulfonylmethane) 20 mg *

MSM is included as a catalyst to help clear any scar tissue associated with drusen deposits.

S-Acetyl Glutathione 10 mg *

Reduced Glutathione is preferable to common Glutathione supplements but is subject to digestion in the gut and in the blood on the way to the retina. We use the more precious S-Acetyl Glutathione form because the addition of the acetyl group not only facilitates crossing the blood-eye barrier but also prevents its digestion until it is taken into the intracellular space, where an enzyme cleaves it off, releasing pre-formed reduced Glutathione into the cytoplasm. "The results suggest that in studies of age-related pathologies, oxidation of GSH may be a more important parameter than a decline in pool size, while in specific pathologies such as diabetes, both oxidation and a decline in pool size may be important." Source: Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes

Nano Chitosan (98% Deacetylated) (Aspergillus niger) 50 mg *

Chitosan binds a wide range of toxins, and the nano-sized particles are small enough to be absorbed into the circulatory system.

L-Lysine 50 mg *

Lysine mobilizes cholesterol deposits such as those in Drusen. This application originates from the only solo two-time Nobel Laureate, Linus Pauling.

Lipase (300 USP) 50 mg *

Lipase taken between meals in an enteric format acts as a systemic enzyme therapy to support mobilization of the fat component of Drusen deposits.

Neutral Protease (Bacillus licheniformis) (11,250 U) 50 mg *

Protease taken between meals in an enteric format acts as a systemic enzyme therapy to support mobilization of the protein component of Drusen deposits.

Microbiome (27 Probiotic Species) 10 mg *

A healthy and diverse microbiome is essential to health. Probiotic flora species produce many important factors, including B vitamins, bulk, and various enzymes.

Bioavailability Factors: 

Phosphatidyl Choline 30% (Gallus gallus domesticus) 21 mg *

Vitamin B3 (as Niacin) 13 mg 65%

EGb 761 (Ginkgo biloba) (24% Flavone Glycosides, 6% Lactones, <0.0005% Ginkgolic Acid) 8 mg *

Moringa 100:1 (Moringa oleifera) 5 mg *

Licorice Omnipotent (Glycyrrhiza glabra) 3 mg *

Gingerol 40% (Zingiber officinalis) 2 mg *

Piperine (Piper nigrum) 1 mg *

Vinpocetine (Vinca minor) 1 mg *

The recommended dosage range is 1 to 2 capsules up to 3 times daily between meals, as guided and according to tolerance.