S-Acetyl Glutathione Background

S-Acetyl Glutathione (SAG) is a modified form of glutathione, a powerful antioxidant naturally produced in the body[3].

Its development can be traced back to at least 1955 when improved methods for its production were patented[5].

SAG was designed to address the poor bioavailability and stability issues associated with standard glutathione supplements[2].

This innovative compound is derived from the fermentation of Saccharomyces cerevisiae and is based on glutathione linked to a sulfur atom[2].

SAG's unique structure allows it to be more easily absorbed into the bloodstream and cross the blood-brain barrier, making it a potent tool for various health applications[3].

S-Acetyl Glutathione Systemic Applications

S-Acetyl Glutathione demonstrates remarkable versatility in systemic applications, ranging from liver protection to overall cellular health[1][2].

It plays a crucial role in maintaining cellular redox state, significantly restoring glutathione levels and glutathione peroxidase (GPx) activity while reducing glutathione disulfide (GSSG) levels and lipid peroxidation in the liver[2].

SAG has shown potential in attenuating carbon tetrachloride-induced liver injury by modulating oxidative imbalance and inflammation[1].

Its ability to improve mitochondrial function and protect against oxidative stress makes it valuable for overall health and disease prevention[3].

S-Acetyl Glutathione for Brain and Cognition

S-Acetyl Glutathione has shown promising effects on cognitive function, particularly in enhancing memory and learning abilities[3].

Studies have demonstrated that glutathione, the precursor to SAG, can improve both learning and memory by enhancing autophagy and hippocampal glutamate levels[3].

Research indicates that SAG may have neuroprotective properties, attributed to its antioxidant and anti-inflammatory compounds, which could help reduce the risk of neurodegenerative diseases like Alzheimer's[3].

Its ability to cross the blood-brain barrier allows it to directly support brain health and function, potentially improving symptoms of cognitive impairment and dementia as we age[3].

S-Acetyl Glutathione for Eye and Vision

S-Acetyl Glutathione has demonstrated potential benefits for eye health, particularly in preventing age-related vision issues[4].

As a precursor to glutathione, SAG helps in preventing macular degeneration, a leading cause of vision loss as we age, by reducing oxidative stress and inflammation in the delicate tissues of the eyes[4].

SAG can help reduce the risk of cataracts by supporting the detoxification of the eye lens, which can become cloudy due to oxidative damage[4].

By maintaining higher levels of glutathione in the body, SAG may help combat age-related vision issues and support clearer vision by promoting cellular health in the eyes[4].

Relevant quotes:

"Glutathione is often referred to as the 'master antioxidant.' It is produced naturally in the body and is found in every cell. Its primary role is to neutralize free radicals, detoxify harmful substances, and support the immune system." - Dr. Gina Nick, naturopathic doctor[4]

Relevant NCBI article quotes:

"S-Acetyl-Glutathione attenuates carbon tetrachloride-induced liver injury by modulating oxidative imbalance and inflammation." - From "S-Acetyl-Glutathione Attenuates Carbon Tetrachloride-Induced Liver Injury by Modulating Oxidative Imbalance and Inflammation" (https://pmc.ncbi.nlm.nih.gov/articles/PMC9024626/)

Functions supported or stimulated:

1. Antioxidant activity[1][2][3][4]

2. Liver protection[1][2]

3. Cellular redox state maintenance[2]

4. Neuroprotection[3]

5. Eye health support[4]

Related benefits:

1. Improved cognitive function and memory[3]

2. Enhanced eye health and protection against age-related vision issues[4]

3. Liver injury attenuation[1]

4. Protection against oxidative stress and inflammation[1][2][3][4]

5. Support for overall cellular health and function[3]

Source Information:

S-Acetyl Glutathione is not derived from a specific plant source but is synthesized through chemical processes or derived from the fermentation of Saccharomyces cerevisiae[2][5].

Citations:

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9024626/

[2] https://www.tandfonline.com/doi/full/10.1080/1828051X.2023.2221073

[3] https://esliteglutathione.com/blogs/news/supporting-brain-health-and-cognitive-function

[4] https://naturallyclearvision.com/glutathione-game-changer-for-vision/

[5] https://patents.google.com/patent/US2760956A/en

[6] https://hormonesynergy.com/blogs/dr-retzlers-longevity-blog/what-is-the-best-glutathione-supplement

[7] https://www.jefferson.edu/about/news-and-events/2020/2/nac-tested-for-multiple-sclerosis.html

[8] https://acuvisionacupuncture.com/10-effective-ways-to-boost-glutathione-for-eye-health/

[9] https://pmc.ncbi.nlm.nih.gov/articles/PMC10421530/