Quercetin Dihydrate Background

Quercetin dihydrate is a naturally occurring flavonoid found in many fruits, vegetables, leaves, seeds, and grains[9].

Its discovery dates back to 1815 when Vogel and Pelletier isolated a "yellow colouring-matter" from plant sources[1].

The chemical structure of quercetin was identified in 1910 by Milobedzka and Lampe as diferuloylmethane[1].

Since its discovery, quercetin has been the subject of extensive research, revealing its potential in treating approximately 80 diseases[1].

Quercetin Dihydrate Systemic Applications

Quercetin dihydrate demonstrates remarkable versatility in systemic applications, ranging from cancer prevention to cardiovascular health[1].

It has shown efficacy in ameliorating cancer insurgences, diabetes mellitus, cardiac complications, and oxidative stress-mediated malfunctions[1].

Quercetin's anti-inflammatory properties make it useful in treating various inflammatory processes, including chronic obstructive pulmonary diseases (COPD)[1].

Its ability to regulate immunity, inhibit inflammation, and scavenge free radicals contributes to its wide-ranging therapeutic potential[1].

Quercetin Dihydrate for Brain and Cognition

Quercetin dihydrate has shown promising effects on cognitive function, particularly as a natural neuroprotective agent[7].

Studies suggest that quercetin contributes to cognitive longevity and may be beneficial in treating several neuronal diseases, including Alzheimer's disease, Parkinson's disease, and depression[3].

Research indicates that quercetin can improve cognitive functions by protecting against oxidative damage of mitochondrial enzymes and preventing apoptosis in Alzheimer's disease[3].

Quercetin Dihydrate for Eye and Vision

Quercetin dihydrate has demonstrated significant benefits for eye health, particularly in preventing and managing age-related macular degeneration (AMD) and cataracts[4].

It helps shield the retina from oxidative stress and inflammation, both known risk factors in the progression of AMD[4].

Quercetin's anti-angiogenic activity has been shown to reduce the proliferation of endothelial cells, their migration, and the formation of new capillaries in vitro, which is particularly relevant for wet AMD[4].

Studies have revealed that quercetin may offer protection against common eye problems, such as cataracts and age-related macular degeneration (AMD)[4].

Relevant quotes:

"These results suggest that taking this relatively safe form of curcumin could provide meaningful cognitive benefits over the years." - Dr. Gary Small, UCLA Longevity Center[2]

"Quercetin is a kind of natural carotenoid that could achieve antioxidant, anti-cancer, lipid-lowering and immune-improving effects." - Frontiers in Veterinary Science[1]

Relevant NCBI article quotes:

"Quercetin has been found to be efficient in ameliorating cancer insurgences, diabetes mellitus, cardiac complications, oxidative stress-mediated malfunctions." - From "Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders"[1]

"The historic background of the Curcuma species begins in Far Eastern medicine and dates back 5,000 (Ayurveda) and 2,000 (Atharveda) years ago, respectively." - From "Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications"[1]

Functions supported or stimulated:

1. Antioxidant activity[1]

2. Anti-inflammatory effects[1]

3. Immune system modulation[1]

4. Neuroprotection[3]

5. Anti-angiogenic activity[4]

Related benefits:

1. Improved cognitive function and memory[3]

2. Potential treatment for neurodegenerative diseases[3]

3. Enhanced eye health, particularly for AMD and cataracts[4]

4. Cancer prevention and treatment[1]

5. Cardiovascular health improvement[1]

Suggested daily human dosage ranges:

500 mg or more daily[2]

Source Information:

Botanical name: Various sources, including Solanum lycopersicum (tomato)[1]

Typical content range: Tomatoes cultivated organically had 79% more quercetin than those grown chemically[1]

Common names:

1. Quercetin[9]

2. Quercetol[9]

3. Sophoretin[9]

4. Meletin[9]

Citations:

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC10674654/

[2] https://www.lifeextension.com/wellness/supplements/quercetin-dihydrate-vs-quercetin

[3] https://onlinelibrary.wiley.com/doi/10.1155/2022/8962149

[4] https://foryouth.co/blogs/magazine/quercetin-eye-health-vision-support

[5] https://pubs.acs.org/doi/10.1021/acsomega.0c01818

[6] https://pmc.ncbi.nlm.nih.gov/articles/PMC7254783/

[7] https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(18)30274-3/fulltext

[8] https://pmc.ncbi.nlm.nih.gov/articles/PMC5594060/

[9] https://en.wikipedia.org/wiki/Quercetin