Trans-Resveratrol Background
Trans-resveratrol, a natural polyphenol compound, was first isolated in 1939 by Michio Takaoka from Veratrum album, variety grandiflorum[1].
Its discovery in red wine in the early 1990s sparked widespread interest in its potential health benefits[5].
Resveratrol is produced in plants via the enzyme resveratrol synthase (stilbene synthase) as a response to stress, injury, or fungal infection[1].
Over the past few decades, extensive research has revealed resveratrol's diverse biological activities, making it a subject of intense scientific investigation for its potential therapeutic applications[5].
Trans-Resveratrol Systemic Applications
Trans-resveratrol demonstrates remarkable versatility in systemic applications, ranging from antioxidant and anti-inflammatory effects to potential benefits in metabolic and cardiovascular health[2].
It has shown efficacy in ameliorating diabetes-related disorders, including inhibition of vascular leakage in early diabetic retinopathy and neovascularization in advanced diabetic retinopathy[2].
Studies have indicated that resveratrol can improve obesity, triglyceride metabolism, blood sugar levels, and insulin sensitivity[2].
Research has also highlighted resveratrol's potential in regulating adipocyte hormones to help reduce obesity and its ability to activate multiple signaling pathways, including AMPK/SIRT1/Nrf2, which contribute to its systemic benefits[2].
Trans-Resveratrol for Brain and Cognition
Trans-resveratrol has shown promising effects on cognitive function, particularly in enhancing memory and learning abilities in older adults[3].
A 24-month randomized, placebo-controlled crossover trial in postmenopausal women demonstrated that resveratrol supplementation resulted in a significant 33% improvement in overall cognitive performance[3].
Research indicates that resveratrol may have neuroprotective properties, which could help reduce the risk of neurodegenerative diseases and cognitive decline associated with aging[7].
Studies have shown that resveratrol can increase hippocampal functional connectivity, which correlates with improvements in memory retention and glucose metabolism[7].
Trans-Resveratrol for Eye and Vision
Trans-resveratrol has demonstrated significant benefits for eye health, particularly in preventing and managing age-related vision issues[4].
Research has shown that resveratrol and its metabolites can cross protective barriers in the eye, offering potential benefits in protecting vision[4].
Studies have revealed resveratrol's potential in treating macular degeneration, open-angle glaucoma, and diabetic retinopathy due to its potent anti-inflammatory and antioxidant properties[4].
In animal models, resveratrol has shown neuroprotective effects against ischemic damage to the retina and photoreceptor cell death in retinal detachment[11].
Relevant quotes:
"Regular supplementation with low-dose resveratrol can enhance cognition, cerebrovascular function and insulin sensitivity in postmenopausal women." - From a study published in Clinical Nutrition[3]
"Resveratrol does have potential in treating macular degeneration, open-angle glaucoma and diabetic retinopathy." - VisiVite[4]
Relevant NCBI article quotes:
"This study provides initial evidence that supplementary resveratrol improves memory performance in association with improved glucose metabolism and increased hippocampal FC in older adults." - From "Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults"[7]
"Ischaemic injury caused visible thinning of the inner retinal layers, but this was reduced in the rats receiving resveratrol." - From "The Role of Resveratrol in Eye Diseases—A Review of the Literature"[11]
Functions supported or stimulated:
1. Antioxidant activity[1][2]
2. Anti-inflammatory effects[2][4]
3. Neuroprotection[7][11]
4. Regulation of glucose metabolism[3][7]
5. Enhancement of cerebrovascular function[3]
Related benefits:
1. Improved cognitive function and memory[3][7]
2. Enhanced eye health and protection against age-related vision issues[4][11]
3. Potential treatment for metabolic syndrome and diabetes-related disorders[2][3]
4. Support for cardiovascular health[2]
5. Possible anti-cancer effects[2][5]
Suggested daily human dosage ranges:
75 mg trans-resveratrol twice-daily[3]
Source Information:
Botanical name: Reynoutria japonica (Japanese knotweed)[1]
Typical content range: Not provided in the search results
Common names:
1. Japanese knotweed[1]
2. Hu Zhang[1]
Citations:
[1] https://en.wikipedia.org/wiki/Resveratrol
[2] https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1408651/full
[3] https://pubmed.ncbi.nlm.nih.gov/32900519/
[4] https://visivite.com/blogs/news/vision-benefits-of-resveratrol
[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC6319551/
[6] https://pmc.ncbi.nlm.nih.gov/articles/PMC9414442/
[7] https://www.jneurosci.org/content/34/23/7862
[8] https://publications.aston.ac.uk/id/eprint/22311/1/Resveratrol_and_the_eye.pdf
[9] https://www.aging-us.com/article/100445/text
[10] https://www.mdpi.com/2072-6643/9/1/27
[11] https://pmc.ncbi.nlm.nih.gov/articles/PMC9317487/
[12] https://pmc.ncbi.nlm.nih.gov/articles/PMC9412308/
[13] https://www.nature.com/articles/s41598-021-81748-w
last chance to access this product for the best price
["*The statements herein have not been evaluated by the Food and Drug Administration.
This is not intended to diagnose, treat, cure, or prevent any disease."] T.D.C.