TMG Background

Trimethylglycine (TMG), also known as betaine, is a naturally occurring compound found in various foods such as spinach, beetroot, and quinoa[7].

Its discovery dates back to the 19th century, but its importance in human health has gained significant attention in recent years[4].

TMG plays a crucial role as a methyl donor in the body, contributing to numerous biochemical processes essential for cellular function and overall health[4].

Research into TMG has expanded rapidly, revealing its potential applications in various fields, including metabolism, cardiovascular health, and cognitive function[2].

TMG Systemic Applications

TMG demonstrates remarkable versatility in systemic applications, ranging from cardiovascular health to athletic performance enhancement[1].

It has shown efficacy in lowering homocysteine levels, which is associated with improved heart health and reduced risk of cardiovascular diseases[1].

TMG plays a vital role in liver health, supporting optimal liver function and metabolism[4].

Its ability to act as an osmolyte helps regulate cellular volume and protect cells against various forms of stress, including oxidative stress[4].

TMG for Brain and Cognition

TMG has shown promising effects on cognitive function, particularly in the context of reducing the risk of dementia and Alzheimer's disease[2].

Studies suggest that TMG's ability to lower homocysteine levels may contribute to improved brain performance and reduced dementia symptoms[2].

Research indicates that TMG may enhance mental clarity, focus, and concentration, making it attractive for those seeking better cognitive function[8].

However, more research is needed to fully understand TMG's impact on cognitive health, as some studies have shown mixed results regarding its effectiveness in improving cognition[9].

TMG for Eye and Vision

While the search results do not provide specific information on TMG's direct effects on eye and vision health, its role in lowering homocysteine levels may have indirect benefits.

High homocysteine levels have been associated with an increased risk of age-related macular degeneration and other eye conditions[4].

By helping to maintain healthy homocysteine levels, TMG may potentially contribute to overall eye health, though more research is needed to confirm this connection.

It's important to note that excessive intake of certain vitamins, such as niacin, can cause eye damage, highlighting the need for caution when using supplements[3].

Relevant quotes:

"TMG may reduce a risk factor for Alzheimer's by lowering homocysteine levels. While this isn't a guaranteed way to prevent Alzheimer's, it's a promising area of research, especially when combined with Omega-3 and B-vitamins." - Dr. Brad Stanfield[2]

"TMG helps your cells regulate their volume. That's because trimethylglycine is an osmolyte." - Life Extension[4]

Relevant NCBI article quotes:

"Methylmalonate, a specific marker of B12 deficiency, may affect cognition by reducing total brain volume whereas the effect of homocysteine (nonspecific to vitamin B12 deficiency) on cognitive performance may be mediated through increased white matter hyperintensity and cerebral infarcts." - From "Vitamin B12, cognition, and brain MRI measures"[5]

Functions supported or stimulated:

1. Methyl donation[4]

2. Homocysteine metabolism[1]

3. Cellular volume regulation[4]

4. Antioxidant activity[4]

5. Liver function support[4]

Related benefits:

1. Improved cardiovascular health[1]

2. Enhanced athletic performance[1]

3. Potential cognitive function improvement[2]

4. Liver health support[4]

5. Cellular stress protection[4]

Suggested daily human dosage ranges:

Up to 15 grams per day may be safe[1]

Source Information:

Botanical sources include spinach, beetroot, and quinoa[7]

Common names:

1. Trimethylglycine

2. Betaine

3. TMG

Citations:

[1] https://www.healthline.com/nutrition/tmg-supplement

[2] https://drstanfield.com/blogs/articles/tmg-betaine-exploding-popularity

[3] https://www.mountsinai.org/about/newsroom/2019/eye-damage-linked-to-popular-over-the-counter-vitamin-that-lowers-cholesterol-can-be-reversed

[4] https://www.lifeextension.com/wellness/supplements/tmg-benefits

[5] https://blog.davincilabs.com/blog/mind-diet-how-dmg-supports-brain-health

[6] https://tmginsuranceservices.com/vision-insurance/

[7] https://moleqlar.com/en/blogs/supplements/betain-tmg-trimethylglycin

[8] https://livelonger.no/en/blogs/articles/tmg-kosttilskudd-fordeler-bruksomrader-og-alt-du-trenger-a-vite

[9] https://www.youtube.com/watch?v=9RyzwCr15Pk

[10] https://donotage.org/blogs/pure-tmg-health-benefits