Serrapeptase Background

Serrapeptase is an extracellular proteolytic enzyme originally discovered in the intestines of the silkworm Bombyx mori in the 1960s[1].

The enzyme was first isolated from the bacteria Serratia marcescens, which plays a critical function in the silkworm's life cycle by dissolving its cocoon[1].

In 1968, serrapeptase was introduced to the Japanese pharmaceutical market for a broad range of medical indications, including anti-inflammatory treatments[1].

By 2011, the Japanese manufacturer voluntarily recalled its anti-inflammatory preparation after postmarketing clinical trials found it ineffective[1].

Serrapeptase Systemic Applications

Serrapeptase demonstrates versatility in systemic applications, including treatment of inflammation, bronchial conditions, and post-surgical swelling[2].

It has been used in various medical fields such as traumatic and postoperative inflammation, laryngitis, bronchitis, gynecology, and dentistry[2].

The enzyme has potential applications in cancer nanomedicine, with studies showing enhanced anti-cancer activity when combined with nanoparticles[2].

Serrapeptase can potentially reduce inflammation and pain in conditions like AIDS and hepatitis B & C infections[2].

Serrapeptase for Brain and Cognition

A study in a rat model of Alzheimer's disease showed that serrapeptase could significantly decrease brain acetylcholinesterase activity and inflammatory markers[7].

Oral administration of serrapeptase resulted in decreased levels of transforming growth factor β, Fas, and interleukin-6[7].

The enzyme treatment also produced significant increases in brain-derived neurotrophic factor and insulin-like growth factor-1 levels[7].

Serrapeptase for Eye and Vision

Serrapeptase may help reduce eye floaters by breaking down protein clusters in the eye's vitreous humor[4].

The enzyme is believed to improve blood circulation, potentially supplying nutrients and oxygen more efficiently to the eyes[4].

Serrapeptase has anti-inflammatory properties that may help reduce inflammation and discomfort in the eyes[4].

Relevant quotes:

"Serrapeptase is a protein-dissolving enzyme capable of digesting proteins" - Vinatura Store[4]

"Serrapeptase can break down protein clusters in the eye's vitreous humor, reducing the formation or presence of eye floaters" - Vinatura Store[4]

Relevant NCBI article quotes:

"Oral administration of SP or NK in a rat model of AD daily for 45 days resulted in a significant decrease in brain AchE activity" - From "Serrapeptase and nattokinase intervention for relieving Alzheimer's disease"[7]

Functions supported or stimulated:

1. Protein breakdown

2. Anti-inflammatory action

3. Blood circulation improvement

4. Biofilm disruption

5. Pain reduction

Related benefits:

1. Potential reduction of eye floaters

2. Post-surgical swelling reduction

3. Inflammation management

4. Potential neurological support

5. Infection prevention

Suggested daily human dosage ranges:

10 mg to 60 mg per day, taken on an empty stomach[4]

Source Information:

Bacterial source: Serratia marcescens ATCC 27117

Common names:

1. Serratiopeptidase

2. Silk worm enzyme

Citations:

[1] https://www.drugs.com/npp/serrapeptase.html

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC9599151/

[3] https://news.mit.edu/2023/new-peptide-may-hold-potential-alzheimers-treatment-0413

[4] https://www.vinatura.store/blogs/articles/benefits-of-serrapeptase-for-eyes

[5] https://pmc.ncbi.nlm.nih.gov/articles/PMC7032259/

[6] https://www.webmd.com/diet/health-benefits-serrapeptase

[7] https://pubmed.ncbi.nlm.nih.gov/23821590/

[8] https://ethoscataracteyedrops.com/serrapeptase.html

[9] https://www.creative-enzymes.com/similar/serrapeptase_652.html

[10] https://specialtyenzymes.com/blog/serrapeptase-literature-review/