Proteoglycans (Convulvulus arvensis) Background

Proteoglycans from Convolvulus arvensis, commonly known as field bindweed, are complex macromolecules extracted from the plant's roots and aerial parts.

The proteoglycan mixture (PGM) was first investigated for its potential biological activities in scientific research conducted in Iran [1].

These compounds represent a diverse group of molecules composed of a core protein with covalently linked glycosaminoglycan (GAG) chains.

The discovery of these proteoglycans has opened new avenues for exploring potential therapeutic applications in various medical fields [1][5].

Proteoglycans (Convulvulus arvensis) Systemic Applications

Proteoglycans from Convolvulus arvensis demonstrate remarkable versatility in systemic applications, including potential anti-tumor and anti-angiogenic properties [1][4].

Studies have shown that the proteoglycan mixture can significantly inhibit the formation of vascular-like tubes in human umbilical vein endothelial cells [1].

The compound has exhibited leishmanicidal activity by suppressing the developmental growth of Leishmania major promastigotes in vitro [1].

Research suggests potential applications in treating cellular proliferation disorders and inhibiting blood vessel growth in various conditions [4].

Proteoglycans (Convulvulus arvensis) for Brain and Cognition

While direct research on brain applications is limited, proteoglycans play crucial roles in nervous tissue development [3].

They can promote or inhibit neurite outgrowth and participate in the specification and maturation of various precursor cell types [3].

Proteoglycans regulate critical neurological processes including cell migration, axonal pathfinding, synaptogenesis, and neural plasticity [3].

Their ability to create dynamic cellular environments and modulate signaling fields suggests potential cognitive and neurological applications [3].

Proteoglycans (Convulvulus arvensis) for Eye and Vision

Proteoglycans from Convolvulus arvensis show potential anti-angiogenic properties relevant to eye health [4].

Research indicates potential applications in treating age-related macular degeneration by inhibiting the growth of abnormal blood vessels [4].

The compound may help prevent intraocular neovascularization, a key factor in macular degeneration [4].

Studies suggest these proteoglycans could potentially be used in combination with other treatments for eye-related proliferative disorders [4].

Relevant quotes:

"Lab studies suggest these extracts may stimulate the immune system and stop the growth of new blood vessels" - Memorial Sloan Kettering Cancer Center [5]

Relevant NCBI article quotes:

"Proteoglycans are diverse, complex extracellular/cell surface macromolecules composed of a central core protein with covalently linked glycosaminoglycan (GAG) chains" - Proteoglycans in brain development and pathogenesis [3]

Functions supported or stimulated:

1. Anti-angiogenesis

2. Immune system stimulation

3. Cell migration regulation

4. Neurite outgrowth modulation

5. Signaling field modulation

Related benefits:

1. Potential cancer growth inhibition

2. Leishmanicidal activity

3. Neurological development support

4. Potential eye health improvement

5. Immune system enhancement

Source Information:

Botanical name: Convolvulus arvensis

Common names:

1. Field bindweed

2. Convolvulus

3. Morning glory family plant

Citations:

[1] https://pubmed.ncbi.nlm.nih.gov/25324459/

[2] https://www.mdpi.com/1420-3049/27/3/963

[3] https://pubmed.ncbi.nlm.nih.gov/29513405/

[4] https://patents.google.com/patent/WO2005089460A2/en

[5] https://www.mskcc.org/cancer-care/integrative-medicine/herbs/convolvulis-arvensis

[6] https://www.fs.usda.gov/database/feis/plants/vine/conarv/all.html

[7] https://pubmed.ncbi.nlm.nih.gov/11015614/

[8] https://www.mdpi.com/2075-1729/12/12/2138

[9] https://www.usbg.gov/sites/default/files/images/fieldbindweed_science_page.pdf

[10] https://www.mdpi.com/2223-7747/12/3/458