• It is safe with no upper limit, unlike any other antioxidant
• Its byproduct when quenching dangerous free radicals is just water
• It is effective orally, so no IV is needed
• It crosses the blood-brain and blood-retina barriers,where it is neuroprotective
  • It is shown to reduce brain damage in Parkinson's
• It can enter the cell, the mitochondria, and the nucleus, improving epigenetic expression of healthy genes, and improving cellular metabolism
  • It improves mitochondrial function
  • It increases insulin sensitivity
  • It decreases high blood sugar
  • It benefits obesity, glucose tolerance, diabetes, and metabolic syndrome
  • It decreases elevated cholesterol levels
  • It restores natural growth and repair of brain cells
  • Allergy is reduced in animal studies via restored cellular homeostasis
  • Cancer prevention is supported, and some protection has been seen against damage caused by chemotherapy

• It neutralizes the most cytotoxic of all Reactive Oxygen Species (ROS):
  • Hydroxyl radical:  H2 + 2(OH) = 2(H2O)
    • Molecular Hydrogen protects DNA against radiation by scavenging Hydroxyl radicals
• It does not quench essential redox-signaling molecules

• It is synergistic with essential oxidizing agents and redox signaling substances (e.g. in ASEA and Humic Acid)
• It is synergistic with local and systemic hyperthermia (e.g. near-infrared photobiomodulation, infrared sauna, and fever)
• It alkalizes the blood, which makes O2 more bioavailable and reduces blood viscosity, allowing better circulation and reduced hypertension
• It stimulates oxidative metabolism, as measured by O2 utilization and CO2 production
  • Muscle fatigue is reduced with exercise due to reduced lactic acid buildup

• Glutathione
• Superoxide Dismutase
• Catalase

• It has a direct anti-inflammatory effect in acute Inflammation:
  • Research documents the benefits in rheumatoid arthritis
  • Animal research shows prevention of muscle wasting in muscular dystrophy
• It reduces chronic pain and inflammation via modulation of epigenetic expression modifiers:
  • It reduces the release of NF-kB
  • It reduces TNFa
  • It reduces excess Nitric Oxide
  • It scavenges peroxynitrite

Here are a few of the thousands of scientific studies and papers on Molecular Hydrogen:

Sources:

1. https://www.nature.com/articles/nm1577
2. https://www.ncbi.nlm.nih.gov/pubmed/26276082
3. https://www.ncbi.nlm.nih.gov/pubmed/11510417
4. https://www.ncbi.nlm.nih.gov/pubmed/23031079
5. https://www.ncbi.nlm.nih.gov/pubmed/26866650
6. https://www.ncbi.nlm.nih.gov/pubmed/22520831
7. https://www.ncbi.nlm.nih.gov/pubmed/24392771
8. https://www.ncbi.nlm.nih.gov/pubmed/21512236
9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865993/
10. https://www.ncbi.nlm.nih.gov/pubmed/21293445
11. https://www.ncbi.nlm.nih.gov/pubmed/22146674
12. https://www.ncbi.nlm.nih.gov/pubmed/27438130
13. https://www.ncbi.nlm.nih.gov/pubmed/19766097
14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257754/
15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731988/

In eye diseases, Molecular Hydrogen provides a broad range of benefits.

"Accumulating evidence suggests that H2 is protective against multiple ophthalmic diseases, including cataracts, dry eye disease, diabetic retinopathy (DR), and other fields. In particular, H2 has been tested in the treatment of dry eye disease and corneal endothelial injury in clinical practice. This medical gas has brought hope to patients suffering from blindness."

Molecular Hydrogen maintains the integrity of the blood-aqueous barrier in uveitis. It prevents the death of cells injured by UV and thermal burns and by ischemia/reperfusion in Glaucoma (anti-apoptotic effect). It helps prevent angiogenesis in damaged retinal and corneal tissues

Animal studies on Glaucoma and Optic Nerve Damage found Molecular Hydrogen:

• Reduces apoptosis (death) of retinal ganglion cells
  • Reduces the levels of IL1-β, TNF-α, and 4-HNE
  • Upregulates GRP78
• Prevents oxidative damage:
  • Reduces lipid peroxidation
  • Clears Peroxynitrite, preventing ONOO-mediated oxidation
• Clears Glutamate
  • Increases EAAT-1

Animal studies on Macular Degeneration show Molecular Hydrogen benefits include:

• Inhibits cellular senescence (unhealthy aging)
• Maintains DNA homeostasis
• Inhibits oxidative stress
• Inhibits apoptosis (cell death)
• Reduces CNV leakage (from leaky neovascular blood vessels in the choroid in wet AMD)
• Reduces photo-oxidative stress from blue light

Various ways of delivering increased Molecular Hydrogen are being researched including:

• Breathing H2 gas, but the pure gas can be explosive, so not for home use
• Injection or drip infusion by medical professionals
• Drinking: must be done frequently as it evaporates
• Eye drops: must be made fresh frequently
• Production by Microbiome: more sustained effects, but more variable due to individual gut ecology, microbiome differences, and dietary fiber differences.
  • 70% of microbiome species produce H2, including Bifidobacteria
  • H2 is produced by fermentation in an anaerobic environment
  • H2 is also consumed as an energy source by both aerobic and anaerobic species
  • H2 in the gut can increase the anti-inflammatory and anti-carcinogenic metabolite Butyrate

Source: Novel Role of Molecular Hydrogen: The End of Ophthalmic Diseases?

 ncbi.nlm.nih.gov/pmc/articles/PMC10674431/