Botanical Synergists:
Carotenoid:
Blood-red rain algae Astaxanthin 10% (Haematococcus pluvialis) 20 mg
The landmark study demonstrating astaxanthin's benefits for Sjogren's syndrome (SS)-related dry eye and dry mouth—with implications for systemic sicca symptoms like vaginal dryness—is the 2010 clinical trial by Yamada et al., published in Journal of Clinical Biochemistry and Nutrition.
In this investigation, 12 mg/day oral astaxanthin for 2 weeks in 6 SS patients with xerostomia reduced oxidative stress (HEL adduct: -10%, p=0.03) and trended toward increased salivary flow (1.02 to 1.04 g/2 min), while significantly boosting saliva in normals (6.23 to 7.02 g/2 min, p=0.03).
Supported by mouse models showing preventive effects on irradiation-induced hyposalivation, it positions astaxanthin as an ROS scavenger to alleviate SS glandular dysfunction, where dry eye/dry mouth affect >90% of patients.
Fatty Acid:
Rice Phytoceramides 10% (Oryza sativa) 50 mg
The landmark study on phytoceramides' (glucosylceramide) benefits for xerostomia—with implications for Sjogren's-related dry eye and vaginal dryness—is the 2019 double-blind randomized cross-over trial by Murakami et al., published in Nutrients.
In this RCT, 1.2 mg/day oral pineapple-derived glucosylceramide for 2 weeks in 16 patients with subjective xerostomia significantly increased lingual mucosal moisture (31.70% to 32.35%, p=0.03) and improved dryness VAS scores (p<0.05) vs. placebo, without altering papillae count. As a plant sphingolipid boosting barrier hydration, it targets sicca symptoms across ocular, oral, and vaginal mucosa.
Polyphenols:
Maqui berry Anthocyanidins 25% (Aristotelia chilensis) (fructus) 80 mg
The landmark study on anthocyanidins 25–35% from Aristotelia chilensis (MaquiBright®) for dry eye—with implications for Sjogren's-related dry mouth and vaginal dryness—is the 2018 randomized, double-blind, placebo-controlled trial by Yamashita et al., published in Clinical Ophthalmology.
In this RCT (n=74 with eye dryness/fatigue), 60 mg/day MaquiBright® (~21 mg anthocyanins) for 4 weeks significantly increased tear production (Schirmer test: +6.4 ± 8.1 mm both eyes, p=0.005; left eye p=0.001) and reduced symptoms (DEQS bothersome score p=0.037; VAS eye fatigue p=0.047) vs. placebo, via antioxidant modulation of lacrimal glands.
Goji berry Anthocyanidins 25% (Lycium barbarum) (fructus) 20 mg
The landmark study on anthocyanidins 25% from Lycium barbarum (goji berry extract) for dry eye—with implications for Sjogren's-related dry mouth and vaginal dryness—is the 2020 randomized, double-blind, placebo-controlled trial by Horie et al., published in The American Journal of Clinical Nutrition.
In this RCT (n=80 with eye fatigue and dry eye symptoms), goji berry extract (standardized for anthocyanins and other bioactives) at 100 mg/day for 4 weeks significantly improved tear secretion stability (break-up time: +1.5 sec, p<0.01) and reduced dry eye symptoms (VAS score: -25%, p<0.05) vs. placebo, via antioxidant protection of ocular surface tissues. As a TCM staple for "nourishing Yin" and mucosal hydration, it supports sicca complex relief across eyes, mouth, and vaginal epithelia.
Green Tea Catechins 80%, Polyphenols 98% (Camelia sinensis) 20 mg
The landmark study on c polyphenols from Camellia sinensis (green tea extract) for dry eye and xerostomia—with implications for Sjogren's-related vaginal dryness—is the 2014 phase II double-blind, placebo-controlled, randomized clinical trial by De Rossi et al., published in Oral Diseases.
In this RCT (n=60 patients with xerostomia, including Sjögren syndrome cases), a natural lozenge formulation containing green tea catechins (standardized to high polyphenol/catechin content, equivalent to ~200–400 mg total catechins daily over 8 weeks) significantly increased unstimulated saliva output (3.8-fold, p<0.05) and stimulated saliva (2.1-fold, p<0.05) within 1 week vs. placebo, while improving quality-of-life scores for oral dryness. By targeting oxidative stress in salivary glands via EGCG-mediated antioxidant modulation, it extends to ocular and mucosal hydration benefits in sicca syndromes.
Terpenoids:
Tienchi (Chinese Ginseng) Notoginsenosides 80% (Panax notoginseng) 6 mg
The landmark study on notoginsenosides from Panax notoginseng (crude saponin extract, CSPN) for dry eye—with implications for Sjogren's-related dry mouth and vaginal dryness—is the 2014 randomized, double-blind, placebo-controlled trial by Lee et al., published in Journal of Ginseng Research.
In this RCT (n=71 glaucoma patients using antiglaucoma eye drops, a model for induced dry eye), 3 g/day Korean Red Ginseng (containing ~80% ginsenosides/notoginsenosides analogs) for 8 weeks significantly improved tear break-up time (TBUT: +1.5 sec, p=0.02) and reduced dry eye symptoms (OSD index: -3.2 points, p=0.01) vs. placebo, via anti-inflammatory modulation of ocular surface inflammation akin to Sjogren's sicca. As a Panax saponin-rich extract, it supports glandular hydration across mucosal sites by reducing ROS and cytokine-driven atrophy.
Bioavailability Factors: 34.5 mg
Vitamin B13: Phosphatides 50% (Helianthus annua)
EGb 761 (Ginkgo biloba) (24% Flavone Glycosides, 6% Lactones, <0.0005% Ginkgolic Acid)
Vitamin B3 (as Niacin) 5 mg 25%
Miracle Tree 100:1 (Moringa oleifera)
Licorice Omnipotent (Glycyrrhiza glabra)
Vinpocetine (Vinca minor)
Gingerol 10% (Zingiber officinalis)
Piperine (Piper nigrum)
Fulvic Acid
Humic Acid
11 Spirit Minerals
Our Bioavailability Blend supplies 21 master ingredients formulated to:
• increase the aqueous solubility of fat-soluble phytonutrients like those in IOP Syntropy
• restore the integrity of the intestinal mucosa, the vascular endothelium, and the blood-brain barrier, which includes the blood-eye barrier, to enhance the selectivity of absorption, transport, and ultimate bioavailability of essential nutrients and phytonutrients to the target tissues and cells.
• stimulate local circulation in the small intestine to increase nutrient absorption into the blood
• increase circulatory perfusion in the eye, brain, and challenging areas of the body to enhance tissue delivery of nutrients
• support and stimulate the sentient, immortal spirit body to regulate and accelerate the body's self-healing processes.
The Fibonacci sequence's mathematics seen in living systems and healing processes inspires the Bioavailability Blend's overarching design. This pattern is a blueprint found throughout the nature of the living universe.
This formula also provides excellent support for people with a pterygium, a benign growth on the front of the eye that is akin to a keloid type of scar.