Comfort: Synovial Syntropy includes an unparalleled array of key coenzymes, minerals, accessory nutrients and phytonutrients to support joint health, repair, and comfort.

Vitamins and Coenzymes:

Vitamin B9 (5-MTHF - Methyl Folate) 200 mcg 50%: This biologically active form of Folate supports overall joint health by aiding in the reduction of inflammation.

Ascorbyl Palmitate (Supplies Vitamin C) 20 mg 33%: Vitamin C is an antioxidant that can help reduce oxidative stress in joints. As the fat-soluble form, it supplies a reservoir of Vitamin C in the cell membranes that maintains the vitamin levels much longer in the tissues.

Vitamin D3 (Cholecalciferol) 400 IU 100%: Essential for calcium absorption, which is crucial for bone and joint health. Vitamin D3 also helps regulate the immune system. Vitamin D3 is more effective than the D2 form, Ergocalciferol.

Vitamin E (Mixed Tocopherols) 30 IU 100%: These are natural D-forms (delta, beta, gamma and alpha) with antioxidant properties that may help reduce inflammation and oxidative damage in joints. Vitamin E also helps repair damaged and scarred tissue.

Vitamin K2 (MK-4 - Menaquinone-4) 1 mg 12,500%: Vitamin K2 supports bone health by aiding in calcium regulation, which is vital for joint integrity. The MK-4 form shows particular promise in potentially alleviating symptoms and slowing the progression of arthritis, both osteoarthritis (OA) and rheumatoid arthritis (RA).

CoQ10 (Ubiquinone) 5 mg: An antioxidant that may help reduce inflammation and protect joint tissues. Studies suggest CoQ10 supplementation can reduce inflammatory markers and oxidative stress in conditions like rheumatoid arthritis.

Minerals:

Boron (Boron Glycinate) 25 mcg: May support bone and joint health by aiding in calcium metabolism. Boron has shown potential in alleviating arthritis symptoms, particularly osteoarthritis, due to its anti-inflammatory and bone health benefits.

Magnesium (Magnesium Glycinate) 1 mg 0.25%: Important for overall bone and muscle health, which indirectly affects joint comfort. Lower magnesium intake is associated with increased knee pain and poorer function in people with osteoarthritis. See related products at the bottom of the page for higher doses.

Selenium (Methylselenocysteine) 70 ncg 199%: An antioxidant that can help protect joint tissues from oxidative damage. Selenium supplementation may help reduce joint pain and improve some disease activity markers in rheumatoid arthritis (RA).

MSM (Methylsulfonylmethane) 10 mg: A sulfur compound that helps reduce joint pain and inflammation. MSM is often used as a dietary supplement to alleviate osteoarthritis (OA) pain and improve joint function. See related products below for higher doses.

Botanical Factors:

Curcumin and Tetrahydrocurcumin (Curcuma longa) 20 mg: These compounds from Turmeric are known for their anti-inflammatory properties; they can help alleviate joint discomfort. Curcumin is fat soluble, while Tetrahydrocurcumin is water soluble, so they go to different locations in the body and have complementary effects. Studies suggest that both compounds can help prevent osteoarthritis symptoms and decrease the expression of pro-inflammatory cytokines in animal models. 

Oligomeric Proanthocyanidin Complexes (Pinus pinaster) 10 mg: These OPC polyphenols from Pine are antioxidants that may reduce inflammation and protect cartilage health by inhibiting the activity of matrix metalloproteinases (MMPs), enzymes that break down cartilage. Some studies also indicate that OPCs may promote the synthesis of hyaluronic acid, which is crucial for maintaining joint fluid viscosity and cartilage health.

Polyphenols (Camelia sinensis) 15 mg: These bioflavonoids from Green Tea are antioxidants that can help reduce oxidative stress in joints. Studies suggest these compounds can inhibit cartilage breakdown, reduce inflammation markers, and potentially offer relief from arthritis symptoms.

Hesperiden Methyl Chalcone (Citrus spp.) 15 mg: This bioflavonoid from Citrus may have anti-inflammatory properties that benefit joint comfort. HMC also stabilizes the mast cell membrane, reducing histamine-related inflammatory reactions. Studies in mice have demonstrated that HMC can reduce symptoms and inflammation associated with different types of arthritis, including TiO2-induced arthritis and experimental gout arthritis.

Quercetin Dihydrate (Sophora japonica) 30 mg: Quercetin is the most researched of all the polyphenols. Known for its antioxidant and anti-inflammatory effects, this bioflavonoid from the Chinese Scholar Tree can help with joint pain and inflammation. Studies suggest it can help reduce inflammation in arthritis by modulating key inflammatory pathways and inhibiting the release of inflammatory cytokines. It may also protect against joint damage and improve symptoms like morning stiffness and pain. The Dihydrate form is water soluble making it about 8 times more effective than the commonly used form.

Trans-Resveratrol (Polygonum cuspidatum) 15 mg: This polyphenol extracted from Japanese knotweed provides antioxidant and anti-inflammatory properties that show promising support for joint health. Studies in animal models of osteoarthritis (OA) and rheumatoid arthritis (RA) have demonstrated that trans-resveratrol can suppress inflammation, reduce cartilage damage, and modulate immune responses.

Ginsenosides (Panax ginseng) 7 mg: These active compounds from Ginseng are adaptogenic and have anti-inflammatory and immune-modulatory properties that benefit joint comfort and protect cartilage against damage.

Notoginsenosides 80% (Panax notoginseng) 7 mg: These adaptogens from Chinese Ginseng support joint health and mitigate arthritis symptoms by reducing inflammation and promoting lymphatic drainage. Studies suggest it works by suppressing the NF-kB signaling pathway, which plays a crucial role in inflammation, and by improving lymphatic drainage, a process that can help remove inflammatory substances from the affected joints.

Thymoquinone 10% (Nigella sativa) 10 mg: This healing compound from Black Seed Oil has anti-inflammatory effects. Studies suggest TQ can reduce inflammation, pain, and joint damage associated with arthritis, including rheumatoid arthritis (RA) and psoriatic arthritis (PsA).

Loganin 10% (Cornus officinalis) 20 mg: This compound from the Japanese Cornelian Cherry has properties that support joint comfort. Studies suggest it can protect against cartilage damage, reduce inflammation, and inhibit the NLRP3 inflammasome, a key player in arthritis development.

Paeoniflorin 50% (Paeonia albiflora) 30 mg: This active compound from Chinese Peony has anti-inflammatory and immunomodulatory effects. It can reduce pain, synovitis, and joint destruction in arthritis models, potentially by suppressing the production of inflammatory mediators and inhibiting the proliferation of immune cells and synovial fibroblasts.

Oxindole Alkaloids 5% (Uncaria tomentosa) 20 mg: These active substances from Cat's Claw help reduce joint inflammation and discomfort by influencing inflammatory pathways and potentially modulating the immune system.

Berberine (Coptis chinensis) 10 mg: This compound extracted from Chinese Goldthread shows promise in treating arthritis, particularly rheumatoid arthritis (RA), by modulating the immune system and reducing inflammation. Studies in animal models of arthritis, like adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA), demonstrate berberine's ability to suppress inflammation, reduce joint damage, and alleviate pain. Berberine's anti-arthritic effects are linked to its immunomodulatory properties, including influencing macrophage polarization and T cell responses.

Huang Bai 5:1 (Phellodendron chinense) 30 mg: This concentrated extract of Chinese Corktree is used in managing various types of arthritis, particularly rheumatoid arthritis (RA) and osteoarthritis (OA), due to its potential anti-inflammatory and cartilage-protective properties.

CBD (Cannabidiol - Cannabis spp.) 5 mg: May have anti-inflammatory and pain-relief properties that benefit joint comfort.

Beta Sitosterol (Urtica dioica) 30 mg: Extracted from Stinging Nettle, this compound reduces inflammation and supports joint health. Studies suggest it can inhibit the proliferation and migration of synovial cells, reduce inflammation, and even mitigate bone erosion in arthritic conditions.

Lycopene 12% (Solanum lycopersicum) 30 mg: This carotenoid from Tomato protects joints from oxidative damage. Studies suggest that lycopene can help reduce joint pain and inflammation, potentially by inhibiting pro-inflammatory cytokines and reducing the expression of inflammatory mediators like COX-2. Furthermore, lycopene may play a role in preventing or slowing the progression of osteoarthritis and rheumatoid arthritis.

Boswellic Acids (Boswellia serrata) 30 mg: These active compounds in Indian Frankincense are known for their anti-inflammatory properties that benefit joint comfort. They can help reduce joint pain and swelling by inhibiting the 5-lipoxygenase enzyme, which is involved in the production of inflammatory molecules called leukotrienes. Some research indicates Boswellia, and specifically boswellic acids, can be effective in managing both osteoarthritis (OA) and RA symptoms.

Silymarin (Silybum marianum) 25 mg: This botanical compound from Blessed Thistle (St. Mary's Thistle) supports liver health, indirectly benefiting joints by aiding in toxin removal. The electroacupuncture vessel for the joints is right next to the liver meridian. We believe this is why certain parasites that tend to infest the liver also show up next in the joints. Studies suggest Silymarin can reduce inflammation markers, improve functional status, and potentially alleviate pain and other symptoms associated with rheumatoid arthritis.

Bioavailability Factors: 34.5 mg

Vitamin B13: Phosphatides 50% (Helianthus annua)

EGb 761 (Ginkgo biloba) (24% Flavone Glycosides, 6% Lactones, <0.0005% Ginkgolic Acid)

Vitamin B3 (as Niacin) 5 mg 25%

Miracle Tree 100:1 (Moringa oleifera)

Licorice Omnipotent (Glycyrrhiza glabra)

Vinpocetine (Vinca minor)

Gingerol 10% (Zingiber officinalis)

Piperine (Piper nigrum)

Fulvic Acid 

Humic Acid  

11 Spirit Minerals

Our Bioavailability Blend supplies 21 master ingredients formulated to:

• increase the aqueous solubility of fat-soluble phytonutrients like those in IOP Syntropy

• restore the integrity of the intestinal mucosa, the vascular endothelium, and the blood-brain barrier, which includes the blood-eye barrier, to enhance the selectivity of absorption, transport, and ultimate bioavailability of essential nutrients and phytonutrients to the target tissues and cells.

• stimulate local circulation in the small intestine to increase nutrient absorption into the blood

• increase circulatory perfusion in the eye, brain, and challenging areas of the body to enhance tissue delivery of nutrients

• support and stimulate the sentient, immortal spirit body to regulate and accelerate the body's self-healing processes.

The Fibonacci sequence's mathematics seen in living systems and healing processes inspires the Bioavailability Blend's overarching design. This pattern is a blueprint found throughout the nature of the living universe.

This formula also provides excellent support for people with a pterygium, a benign growth on the front of the eye that is akin to a keloid type of scar.